67镓和111铟标记的转铁蛋白的体外稳定性
Stabilities of 67ga- and 111In-labeled transferrin in vitro.
作者信息
Ohtake Yosuke, Maruko Akiko, Kuwahara Yoshikazu, Fukumoto Manabu, Ohkubo Yasuhito
机构信息
Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan.
出版信息
Protein Pept Lett. 2009;16(2):138-42. doi: 10.2174/092986609787316298.
We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111In-DTPA-Tf was also the most stable radiolabeled transferrin in the blood.
我们试图开发一种稳定的放射性标记转铁蛋白（Tf），用于与Tf受体相关的实验研究。使用67Ga和111In作为标记放射性同位素。凝胶色谱、透析和电泳的结果表明，在本研究中检测的放射性标记Tf中，111In-DTPA-Tf是最稳定的。111In-DTPA-Tf也是血液中最稳定的放射性标记转铁蛋白。
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