Stabholz A, Soskolne W A, Friedman M, Sela M N
Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
J Periodontol. 1991 Jul;62(7):429-33. doi: 10.1902/jop.1991.62.7.429.
The release of chlorhexidine from an ethyl cellulose-based dosage form (SRD) has been shown to be effective in the reduction of the flora associated with periodontal pockets as well as in reducing probing depths. In this study, treatment with this dosage form was compared to routine maintenance therapy (RMT) in a 2-year, split mouth clinical trial. Ten patients with 84 pockets greater than or equal to 5 mm who had not received any periodontal therapy or systemic antibiotics over the last 6 months were included. The patients all received a full mouth scaling and root planing together with through oral hygiene instruction. Two months later (baseline) plaque index (P1I), bleeding on probing (BOP), pocket probing depth (PD), and attachment levels (AL) were assessed at all selected sites. Pockets on the control side then received RMT while the experimental pockets were treated with the SRD only. Treatment was repeated every 3 months for 2 years. The SRD treatment resulted in an improvement of greater than or equal to 3 mm in PD of at least 1 pocket in 8 of 10 patients, while RMT resulted in a similar improvement in only 1 of 10 patients (P = 0.012). Similarly a gain of attachment of greater than or equal to 3 mm was found in at least 1 SRD pocket in 8 of 10 patients. The RMT resulted in a similar improvement in only 2 patients (P = 0.012).(ABSTRACT TRUNCATED AT 250 WORDS)
已证明，洗必泰从乙基纤维素基剂型（SRD）中的释放，对于减少与牙周袋相关的菌群以及降低探诊深度有效。在本研究中，在一项为期2年的半口临床试验中，将这种剂型的治疗与常规维持治疗（RMT）进行了比较。纳入了10名患者，他们有84个深度大于或等于5mm的牙周袋，且在过去6个月内未接受过任何牙周治疗或全身抗生素治疗。所有患者均接受了全口洁治和根面平整以及全面的口腔卫生指导。两个月后（基线），在所有选定部位评估菌斑指数（P1I）、探诊出血（BOP）、牙周袋探诊深度（PD）和附着水平（AL）。对照侧的牙周袋接受RMT治疗，而试验侧的牙周袋仅用SRD治疗。治疗每3个月重复一次，持续2年。SRD治疗使10名患者中的8名患者至少有1个牙周袋的PD改善大于或等于3mm，而RMT仅使10名患者中的1名患者有类似改善（P = 0.012）。同样，10名患者中的8名患者至少有1个SRD牙周袋的附着增加大于或等于3mm。RMT仅使2名患者有类似改善（P = 0.012）。（摘要截短于250字）
