Zachariah Donah, Kalra Philip A, Kalra Paul R
Department of Cardiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK.
J Ren Care. 2009 Mar;35(1):2-10. doi: 10.1111/j.1755-6686.2009.00069.x.
Chronic kidney disease and chronic heart failure are closely interlinked; an abnormality in one system adversely impacts upon the function of the other. Despite the wealth of evidence available for beneficial treatment strategies in chronic heart failure, the prognosis remains poor and optimum therapy under-utilised. The applicability of proven therapies to patients with co-morbidity remains a particular challenge, especially since marked renal impairment has often been an exclusion criteria in major studies. In this article we discuss the epidemiology and pathophysiology of the two conditions and then focus on the aspects of treatment most pertinent to those patients with heart failure patients and concomitant chronic kidney disease.
慢性肾脏病与慢性心力衰竭密切相关；一个系统的异常会对另一个系统的功能产生不利影响。尽管有大量证据表明慢性心力衰竭存在有益的治疗策略，但预后仍然很差，最佳治疗方法未得到充分利用。已证实的治疗方法对合并症患者的适用性仍然是一个特殊挑战，特别是因为在主要研究中，明显的肾功能损害常常是排除标准。在本文中，我们讨论这两种疾病的流行病学和病理生理学，然后重点关注与心力衰竭合并慢性肾脏病患者最相关的治疗方面。
