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通过C3的CD21信号传导调节浦肯野细胞蛋白4的表达。

CD21 signaling via C3 regulates Purkinje cell protein 4 expression.

作者信息

Jacobson Amanda C, Weis Janis J, Weis John H

机构信息

Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

出版信息

Mol Immunol. 2009 Apr;46(7):1488-93. doi: 10.1016/j.molimm.2008.12.030. Epub 2009 Feb 7.

DOI:10.1016/j.molimm.2008.12.030
PMID:19201479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2688825/
Abstract

Complement receptor proteins CR2 (CD21) and CR1 (CD35) have been identified as components of the murine B cell co-receptor complex. Gene expression profiles between naïve WT, C3-/-, and CD21/35-/- B cells demonstrate enhanced expression of a Ca(2+)-modulating gene, Pcp4, in WT mice compared to the complement-deficient animals. Increased expression of Pcp4 is also coincident with B cell maturation into end stage phenotypes. Prolonged activation of B cells via cross-linking of the BCR (but not CR1/CR2 alone) leads to increased expression of Pcp4 and suppressed Ca(2+) release. In total these data demonstrate that the expression of Pcp4 in naïve resting mature B cells is dependent upon tonic stimulation from the CR1/CR2 proteins via a C3 ligand, and that antigen specific B cell activation can also elevate Pcp4 expression that is coincident with suppression of calcium-dependent responses.

摘要

补体受体蛋白CR2（CD21）和CR1（CD35）已被鉴定为小鼠B细胞共受体复合物的组成部分。幼稚野生型、C3-/-和CD21/35-/- B细胞之间的基因表达谱表明，与补体缺陷动物相比，野生型小鼠中一种钙调节基因Pcp4的表达增强。Pcp4表达的增加也与B细胞成熟为终末表型同时发生。通过BCR交联（但不单独通过CR1/CR2）对B细胞进行长时间激活会导致Pcp4表达增加和Ca(2+)释放受抑制。这些数据总体表明，幼稚静止成熟B细胞中Pcp4的表达依赖于通过C3配体由CR1/CR2蛋白产生的张力刺激，并且抗原特异性B细胞激活也可提高Pcp4表达，这与钙依赖性反应的抑制同时发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/f41210b64cf3/nihms108761f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/69a2407a5a2b/nihms108761f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/acfd0372398e/nihms108761f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/0df0542ca591/nihms108761f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/f41210b64cf3/nihms108761f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/69a2407a5a2b/nihms108761f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/acfd0372398e/nihms108761f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/0df0542ca591/nihms108761f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df5/2688825/f41210b64cf3/nihms108761f4.jpg

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本文引用的文献

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Defining a transcriptional fingerprint of murine splenic B-cell development.定义小鼠脾脏B细胞发育的转录指纹图谱。
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