Sleiman Joseph N, Kohlhoff Stephan A, Roblin Patricia M, Wallner Sabine, Gross Richard, Hammerschlag Margaret R, Zenilman Michael E, Bluth Martin H
Department of 1Pediatrics and 3Surgery, SUNY Downstate Medical Center, Brooklyn, New York, USA.
Ann Clin Lab Sci. 2009 Winter;39(1):60-3.
Sophorolipids (SLs), glycolipids produced by yeasts, have been reported to have immunomodulating activity and to reduce the mortality rate in animal models of sepsis. In the present study, the antibacterial activities of SLs and several derivatives were tested against a selection of standard bacterial isolates using the broth microdilution method. The SL derivatives tested did not show any significant antibacterial activity in vitro when tested at clinically relevant concentrations. Most likely the reported decrease of mortality rate in the rat septic shock model was not secondary to antibacterial activity of SLs. The SLs may be used as anti-inflammatory agents or immunomodulators without affecting the host's bacterial flora.
槐糖脂（SLs）是酵母产生的糖脂，据报道具有免疫调节活性，并能降低脓毒症动物模型的死亡率。在本研究中，使用肉汤微量稀释法测试了槐糖脂及其几种衍生物对一系列标准细菌分离株的抗菌活性。所测试的槐糖脂衍生物在临床相关浓度下进行体外测试时，未显示出任何显著的抗菌活性。很可能在大鼠脓毒性休克模型中报道的死亡率降低并非槐糖脂抗菌活性的继发作用。槐糖脂可作为抗炎剂或免疫调节剂使用，而不影响宿主的细菌菌群。
