Combaluzier Benoit, Mueller Philipp, Massner Jan, Finke Daniela, Pieters Jean
Biozentrum, University of Basel, Basel, Switzerland.
J Immunol. 2009 Feb 15;182(4):1954-61. doi: 10.4049/jimmunol.0801811.
Coronin 1 is a leukocyte specific regulator of Ca(2+)-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca(2+) mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo.
冠蛋白1是白细胞中钙依赖性信号传导的特异性调节因子，对外周T淋巴细胞的存活至关重要，但其在B细胞中的作用尚不清楚。在本研究中，我们发现冠蛋白1对于BCR触发后的细胞内钙动员和增殖至关重要。然而，共刺激信号的存在使得冠蛋白1对于B细胞信号传导不再必要，这与冠蛋白1缺陷小鼠针对多种抗原产生正常免疫反应一致。我们得出结论，冠蛋白1虽然对T细胞功能和存活至关重要，但在体内对B细胞功能并非必需。
