Cheung Chee Kay, Bhandari Sunil
Department of Renal Medicine, Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom.
Clin J Am Soc Nephrol. 2009 Feb;4(2):258-60. doi: 10.2215/CJN.05151008.
The introduction of estimated GFR (eGFR) reporting based on the Modification of Diet in Renal Disease (MDRD) equation has caused much debate regarding its value in the wider community. In particular, automated reporting of eGFR by laboratories has led to concern that it is being used as a "covert " screening tool, in populations in which the MDRD equation has known inaccuracies. There is a fear of creating a population of "worried well, " with potential impact on patients and implications for the use of resources. It is established that in certain groups, chronic kidney disease confers a greatly increased risk of cardiovascular disease, yet risk factors remain inadequately managed. We believe that eGFR reporting allows the opportunity to stratify risk and improve outcome among a wide population.
基于肾脏病饮食改良(MDRD)公式的估算肾小球滤过率(eGFR)报告的引入,在更广泛的群体中引发了关于其价值的诸多争论。特别是实验室对eGFR的自动报告引发了人们的担忧,即在MDRD公式已知存在不准确之处的人群中,它正被用作一种“隐蔽”的筛查工具。人们担心会产生一群“过度担忧健康的人”,这可能对患者产生影响,并对资源利用产生影响。已确定在某些群体中,慢性肾脏病会大大增加心血管疾病的风险,但风险因素仍未得到充分管理。我们认为,eGFR报告为在广大人群中进行风险分层和改善结局提供了机会。