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基层医疗诊所中估算肾小球滤过率的报告。

Reporting of estimated GFR in the primary care clinic.

作者信息

Wyatt Christina, Konduri Vinaya, Eng John, Rohatgi Rajeev

机构信息

Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA.

出版信息

Am J Kidney Dis. 2007 May;49(5):634-41. doi: 10.1053/j.ajkd.2007.02.258.

Abstract

BACKGROUND

Because serum creatinine is an insensitive measure of kidney dysfunction, guidelines have advocated routine use of estimated glomerular filtration rate (eGFR) to identify patients with chronic kidney disease (CKD). Patients with early (stage 3) CKD remain undiagnosed in primary care clinics; therefore, we hypothesized that routine reporting of eGFR in outpatient clinics would improve the recognition and treatment of CKD.

METHODS

A retrospective review of primary care patients was undertaken at the Bronx Veterans Affairs Medical Center, Bronx, New York, before and after the institution of routine eGFR reporting. We evaluated the achievement of diagnostic and therapeutic treatment goals based on the Kidney Disease Outcomes Quality Initiative guidelines (documentation of CKD, urinalysis assessment, blood pressure < 130/80 mm Hg, and renin-angiotensin system blockade) for patients with stage 3 CKD during each period.

RESULTS

Overall, patients with diabetes with early-stage CKD achieved superior treatment rates than similar patients without diabetes. Routine reporting of eGFR improved the documentation and identification of CKD by almost 50%, although absolute improvement was modest. Use of renin-angiotensin system blockers improved minimally, as did blood pressure control. Patients with documented CKD achieved treatment goals more frequently than patients without documented CKD.

CONCLUSION

Routine reporting of eGFR alone modestly improved the identification of patients with CKD without a clinically significant effect on care. For Modification of Diet in Renal Disease Study calculation of eGFR reporting to effect improvements in CKD care, it will be necessary to pair eGFR reporting with provider education to identify these patients and treat them effectively.

摘要

背景

由于血清肌酐对肾功能障碍的检测并不敏感,相关指南提倡常规使用估算肾小球滤过率(eGFR)来识别慢性肾脏病(CKD)患者。早期(3期)CKD患者在初级保健诊所仍未得到诊断;因此,我们推测在门诊常规报告eGFR将改善CKD的识别与治疗。

方法

在纽约州布朗克斯区的布朗克斯退伍军人事务医疗中心,对常规报告eGFR前后的初级保健患者进行了回顾性研究。我们根据肾脏病预后质量倡议指南(CKD的记录、尿液分析评估、血压<130/80 mmHg以及肾素-血管紧张素系统阻断)评估了各时期3期CKD患者的诊断和治疗目标达成情况。

结果

总体而言,患有早期CKD的糖尿病患者比无糖尿病的类似患者实现了更高的治疗率。eGFR的常规报告使CKD的记录和识别提高了近50%,尽管绝对改善幅度不大。肾素-血管紧张素系统阻滞剂的使用改善甚微,血压控制情况也是如此。有CKD记录的患者比无CKD记录的患者更频繁地实现治疗目标。

结论

仅常规报告eGFR适度改善了CKD患者的识别,对治疗并无临床显著影响。对于肾脏病饮食改良研究中计算eGFR报告以改善CKD治疗而言,有必要将eGFR报告与医生教育相结合,以识别这些患者并进行有效治疗。

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