SHRSP大鼠中Abcg5的错义突变不会加速植物甾醇的肠道吸收：与Wistar大鼠的比较。
Missense mutation in Abcg5 in SHRSP rats does not accelerate intestinal absorption of plant sterols: comparison with Wistar rats.
作者信息
Hamada Tadateru, Kodama Yoko, Goto Hitomi, Yoshida Takeshi, Imaizumi Katsumi, Ikeda Ikuo
机构信息
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
出版信息
Biosci Biotechnol Biochem. 2009 Feb;73(2):361-5. doi: 10.1271/bbb.80594. Epub 2009 Feb 7.
Stroke-prone spontaneously hypertensive rats (SHRSP) deposit plant sterols in their bodies and have a mutation in ATP binding cassette transporter G5 (Abcg5). Lymphatic recovery rates of campesterol and sitosterol in SHRSP rats were comparable to those in Wistar rats, a strain that does not deposit plant sterols in the body and has no mutation in Abcg5. Higher absorption of stigmasterol and sitostanol was observed in SHRSP rats than in Wistar rats, but the differences between SHRSP and Wistar rats were quite small, because the absorbed amounts of these two sterols were much lower than those of campesterol and sitosterol. The in situ uptake of (3)H-sitosterol and (14)C-cholesterol solubilized in the bile salt micelle into intestinal mucosa was comparable between SHRSP and Wistar rats. These observations suggest that a mutation in Abcg5 does not greatly influence intestinal absorption of plant sterols in SHRSP rats, at least in comparison with Wistar rats.
易患中风的自发性高血压大鼠（SHRSP）在其体内沉积植物甾醇，并且在ATP结合盒转运蛋白G5（Abcg5）中存在突变。SHRSP大鼠中菜油甾醇和豆甾醇的淋巴回收率与Wistar大鼠相当，Wistar大鼠是一种不在体内沉积植物甾醇且Abcg5无突变的品系。与Wistar大鼠相比，在SHRSP大鼠中观察到豆甾烯醇和谷甾烷醇的吸收更高，但SHRSP大鼠和Wistar大鼠之间的差异相当小，因为这两种甾醇的吸收量远低于菜油甾醇和豆甾醇。SHRSP大鼠和Wistar大鼠之间，溶解在胆盐微团中的（3）H-豆甾醇和（14）C-胆固醇原位摄取到肠粘膜的情况相当。这些观察结果表明，至少与Wistar大鼠相比，Abcg5中的突变对SHRSP大鼠中植物甾醇的肠道吸收没有很大影响。
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