Hamada Tadateru, Kodama Yoko, Imaizumi Katsumi, Ikeda Ikuo
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Biosci Biotechnol Biochem. 2009 Dec;73(12):2777-8. doi: 10.1271/bbb.90537. Epub 2009 Dec 7.
The lymphatic recovery of radiolabeled sitosterol administered in various amounts to the stomach was almost the same between stroke-prone spontaneously hypertensive rats (SHRSPs), a strain having a missense mutation in ATP binding cassette transporter g5 (Abcg5), and Wistar rats, a normal strain. The results suggest that the mutation of Abcg5 in SHRSPs, compared with Wistar rats, did not influence the ability for intestinal sitosterol absorption regardless of the dose.
给易中风自发性高血压大鼠（SHRSPs，该品系在ATP结合盒转运蛋白g5（Abcg5）中存在错义突变）和正常品系的Wistar大鼠的胃中给予不同剂量的放射性标记谷甾醇，二者的淋巴回收情况几乎相同。结果表明，与Wistar大鼠相比，SHRSPs中Abcg5的突变无论剂量如何，均不影响肠道对谷甾醇的吸收能力。
