Coppola G, Corrado E, Augugliaro S, Mulè M C, Rotolo A, Ciaramitaro G, Farinella M, Evola G, Novo G, Evola S, Andolina G, Caruso M, Cospite V, Vitale F, Hoffmann E, Assennato P, Novo S
Secondary Prevention, Unit of Cardiology, Department of Internal Medicine, Paolo Giaccone Policlinic, University of Palermo, Palermo, Italy.
Minerva Cardioangiol. 2009 Feb;57(1):13-21.
The clinical and prognostic role of cardiac natriuretic peptides (CNP) in patients with heart failure is well known; recently, several studies have evaluated the possibility of using CNP to evaluate their potential prognostic role in patients with acute coronary syndromes (ACS). The aim of this study was to evaluate the short term prognostic value of NT-proBNP in 70 patients admitted for ACS.
The authors studied 70 patients with ACS, evaluating, at admission, clinical-anamnestic, instrumental and laboratory characteristics including NT-proBNP plasma levels. Patients were monitored in a 6-month-follow-up to record adverse fatal events and their possible correlation with baseline characteristics.
The incidence of adverse events during the follow-up period was 28% (10 patients). In patients with adverse events, the authors observed lower left ventricle ejection fraction (P=0.01), higher prevalence of ST elevation myocardial infarction (P=0.03) and higher NT-proBNP levels (P=0.03), compared to those without adverse events. Moreover, the logistic regression analysis underlined how ST elevation myocardial infarction (P=0.05) and higher NT-proBNP levels (P=0.05) were the only predictive variables for adverse events during the follow up period.
This study demonstrates the short term prognostic role of NT-pro BNP in patients admitted for ACS.
心钠素（CNP）在心力衰竭患者中的临床及预后作用已广为人知；最近，多项研究评估了使用CNP来评估其在急性冠状动脉综合征（ACS）患者中潜在预后作用的可能性。本研究的目的是评估70例因ACS入院患者中NT-proBNP的短期预后价值。
作者研究了70例ACS患者，在入院时评估其临床病史、检查及实验室特征，包括血浆NT-proBNP水平。对患者进行为期6个月的随访，记录不良致命事件及其与基线特征的可能相关性。
随访期间不良事件的发生率为28%（10例患者）。与无不良事件的患者相比，发生不良事件的患者左心室射血分数较低（P=0.01），ST段抬高型心肌梗死的患病率较高（P=0.03），NT-proBNP水平较高（P=0.03）。此外，逻辑回归分析强调ST段抬高型心肌梗死（P=0.05）和较高的NT-proBNP水平（P=0.05）是随访期间不良事件的唯一预测变量。
本研究证明了NT-proBNP在因ACS入院患者中的短期预后作用。
