Perille A L, Matus R E
Department of Medicine, Animal Medical Center, New York, NY 10021.
J Vet Intern Med. 1991 May-Jun;5(3):195-8. doi: 10.1111/j.1939-1676.1991.tb00947.x.
Chronic ehrlichiosis was diagnosed in six dogs on the basis of increased immunofluorescent antibody titers to Ehrlichia canis. Although clinical signs varied, all six dogs were anemic, hyperglobulinemic, and an IgG monoclonal gammopathy was documented in five dogs in which serum protein electrophoreses were performed. All dogs were treated with tetracycline for at least 14 days; four dogs also received immunosuppressive drugs. Clinical signs resolved within 1 week, hematologic abnormalities resolved in 1 to 5 months, and increased globulin concentrations normalized in 1 to 15 months; however, E. canis antibody titers remained increased for 15 to 31 months after initiation of treatment. Results of this study show that increased E. canis titers can persist in dogs with ehrlichiosis for many months after clinical recovery.
根据针对犬埃立克体的免疫荧光抗体效价升高，确诊了6只犬患有慢性埃立克体病。尽管临床症状各异，但所有6只犬均贫血、球蛋白血症，并且在5只进行血清蛋白电泳的犬中记录到IgG单克隆丙种球蛋白病。所有犬均接受四环素治疗至少14天；4只犬还接受了免疫抑制药物治疗。临床症状在1周内缓解，血液学异常在1至5个月内缓解，球蛋白浓度升高在1至15个月内恢复正常；然而，治疗开始后15至31个月，犬埃立克体抗体效价仍持续升高。本研究结果表明，埃立克体病犬临床恢复后，犬埃立克体效价升高可能持续数月。
