Hunter T, Sun H
Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 920137-1099, USA.
Ernst Schering Found Symp Proc. 2008(1):1-16. doi: 10.1007/2789_2008_098.
Several ways in which the SUMO and ubiquitin pathways can intersect and communicate have recently been discovered. This review discusses the principles of crosstalk between SUMOylation and ubiquitination, focusing on the RNF4 family of RING finger E3 ubiquitin ligases, which specifically recognize SUMOylated proteins via their SUMO moiety for ubiquitination.
最近发现了几种SUMO和泛素途径可以相互交叉和交流的方式。本综述讨论了SUMO化和泛素化之间的串扰原理，重点关注RING指E3泛素连接酶的RNF4家族，该家族通过其SUMO部分特异性识别SUMO化蛋白以进行泛素化。
