Ito Ayaka, Suganami Takayoshi, Ogawa Yoshihiro
Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University.
Nihon Rinsho. 2009 Feb;67(2):270-6.
Evidence has accumulated suggesting that obesity is a state of chronic, low grade inflammation; it may represent a potential mechanism whereby obesity leads to the metabolic derangements. To understand the molecular mechanism underlying the development of obesity and obesity-related metabolic syndrome, it is of great use to divide the obesity-related 'adipose tissue remodeling' into three phases; 1) adipocyte proliferation and hypertrophy, 2) macrophage infiltration, and 3) adipocyte-macrophage interaction. Elucidation of the molecular mechanism underlying the inflammatory changes in each phase of the obesity-related 'adipose tissue remodeling' may lead to the identification of new therapeutic targets that may reduce obesity-induced inflammatory changes and thus the metabolic syndrome.
越来越多的证据表明，肥胖是一种慢性低度炎症状态；它可能代表了肥胖导致代谢紊乱的潜在机制。为了理解肥胖及肥胖相关代谢综合征发生发展的分子机制，将肥胖相关的“脂肪组织重塑”分为三个阶段非常有用；1）脂肪细胞增殖和肥大，2）巨噬细胞浸润，3）脂肪细胞与巨噬细胞相互作用。阐明肥胖相关“脂肪组织重塑”各阶段炎症变化的分子机制，可能会找到新的治疗靶点，从而减轻肥胖引起的炎症变化以及代谢综合征。
