Mitsuishi Masanori, Miyashita Kazutoshi, Itoh Hiroshi
Department of Internal Medicine, School of Medicine, Keio University.
Nihon Rinsho. 2009 Feb;67(2):321-6.
Metabolic syndrome, which is consisted of hypertension, dyslipidemia and impaired glucose tolerance, is one of the most significant lifestyle-related disorders that lead to cardiovascular diseases. Among many upstream factors that are related to metabolic syndrome, obesity, especially visceral obesity, plays an essential role in its pathogenesis. In recent studies, possible mechanisms which connect obesity to metabolic syndrome have been elucidated, such as inflammation, abnormal secretion of adipokines and mitochondrial dysfunction. In this review, we focus on the relationship between obesity and metabolic syndrome; and illustrate how visceral obesity contributes to, and how the treatments for obesity act on metabolic syndrome.
代谢综合征由高血压、血脂异常和糖耐量受损组成，是导致心血管疾病的最重要的生活方式相关疾病之一。在与代谢综合征相关的众多上游因素中，肥胖尤其是内脏肥胖在其发病机制中起着至关重要的作用。在最近的研究中，已经阐明了将肥胖与代谢综合征联系起来的可能机制，如炎症、脂肪因子分泌异常和线粒体功能障碍。在这篇综述中，我们重点关注肥胖与代谢综合征之间的关系；并阐述内脏肥胖如何导致代谢综合征，以及肥胖治疗如何作用于代谢综合征。
