钯（II）催化芳基碘化物的交叉偶联制备不对称联芳烃。
Preparation of unsymmetrical biaryls by Pd(II)-catalyzed cross-coupling of aryl iodides.
机构信息
Department of Chemistry, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
出版信息
Org Lett. 2009 Mar 5;11(5):1079-82. doi: 10.1021/ol802865c.
PMID:19203254
Abstract
The Ullmann homo- and cross-couplings of aryl iodides are carried out to afford symmetrical and unsymmetrical biaryls in moderate to good yields in a catalytic system of Pd(OAc)(2)/K(2)CO(3)/MeCOEt. The high selectivity of unsymmetrical biaryl products in cross-couplings mainly depends on the reactivity difference between two iodoarene substrates and their employed ratios.
摘要
在 Pd(OAc)(2)/K(2)CO(3)/MeCOEt 催化体系中，通过乌尔曼同偶联和交叉偶联反应，芳基碘可以中等至良好的产率得到对称和不对称联苯产物。在交叉偶联反应中，不对称联苯产物的高选择性主要取决于两个碘代芳烃底物的反应活性差异及其使用比例。
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