Laboratoire de Synthèse et Etude de Systèmes d'Intérêt Biologique, SEESIB (UMR 6504-CNRS), Université Blaise Pascal-Clermont-Ferrand 2, 24 avenue des Landais, 63177 Aubière Cedex, France.
Org Lett. 2009 Mar 5;11(5):1167-70. doi: 10.1021/ol900048r.
A short, convergent, formal total synthesis of cyclotheonamide C is described. The key linear pentapeptide intermediate is assembled at the same time as the elaboration of the alpha-hydroxyhomoarginine (H-hArg) residue via a three-component Passerini reaction-amine deprotection-O,N-acyl migration strategy.
本文描述了环硫菌胺 C 的一种简短、汇聚、形式上的全合成方法。关键的线性五肽中间体通过三组分 Passerini 反应-胺脱保护-O，N-酰基迁移策略同时组装，并对α-羟基同型精氨酸（H-hArg）残基进行了修饰。
