促肾上腺皮质激素对肌肉乙酰胆碱酯酶和非特异性酯酶的影响。
Effect of adrenocorticotrophic hormone on muscle acetylcholinesterase and nonspecific esterase.
作者信息
Chokroverty S, Bernsohn J, Reyes M G, Chokroverty M
出版信息
Acta Neurol Scand. 1977 Mar;55(3):226-30. doi: 10.1111/j.1600-0404.1977.tb05641.x.
Abstract
Acetylcholinesterases in the muscle homogenates of hamsters receiving ACTH intraperitoneally for six weeks were reduced as compared to the activities in the control samples. In polyacrylamide disc gel electrophoresis of the ACTH-treated muscles some acetylcholinesterase bands were absent. These observations may be significant in explaining the ACTH-induced improvement in myasthenia gravis patients and in the pathophysiology of steroid myopathy.
摘要
与对照样本的活性相比，腹腔注射促肾上腺皮质激素六周的仓鼠肌肉匀浆中的乙酰胆碱酯酶减少。在促肾上腺皮质激素处理过的肌肉的聚丙烯酰胺圆盘凝胶电泳中，一些乙酰胆碱酯酶条带消失。这些观察结果对于解释促肾上腺皮质激素诱导重症肌无力患者病情改善以及类固醇肌病的病理生理学可能具有重要意义。
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