Goswami Ravinder, Marwaha Raman Kumar, Gupta Nandita, Tandon Nikhil, Sreenivas Vishnubhatla, Tomar Neeraj, Ray Debarti, Kanwar Ratnesh, Agarwal Rashmi
Department of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Br J Nutr. 2009 Aug;102(3):382-6. doi: 10.1017/S0007114509220824. Epub 2009 Feb 10.
25-Hydroxy vitamin D (25(OH)D) deficiency is linked with predisposition to autoimmune type 1 diabetes and multiple sclerosis. Our objective was to assess the relationship between serum 25(OH)D levels and thyroid autoimmunity. Subjects included students, teachers and staff aged 16-60 years (total 642, 244 males, 398 females). Serum free thyroxine, thyroid-stimulating hormone (TSH), and thyroid peroxidase autoantibodies (TPOAb), intact parathyroid hormone and 25(OH)D were measured by electrochemiluminescence and RIA, respectively. Thyroid dysfunction was defined if (1) serum TSH > or = 5 microU/ml and TPOAb>34 IU/ml or (2) TSH > or = 10 microU/ml but normal TPOAb. The mean serum 25(OH)D of the study subjects was 17.5 (sd 10.2) nmol/l with 87 % having values < or = 25 nmol/l. TPOAb positivity was observed in 21 % of subjects. The relationship between 25(OH)D and TPOAb was assessed with and without controlling for age and showed significant inverse correlation (r - 0.08, P = 0.04) when adjusted for age. The prevalence of TPOAb and thyroid dysfunction were comparable between subjects stratified according to serum 25(OH)D into two groups either at cut-off of < or = 25 or >25 nmol/l or first and second tertiles. Serum 25(OH)D values show only weak inverse correlation with TPOAb titres. The presence of such weak association and narrow range of serum 25(OH)D did not allow us to interpret the present results in terms of quantitative cut-off values of serum 25(OH)D. Further studies in vitamin D-sufficient populations with wider range of serum 25(OH)D levels are required to substantiate the findings of the current study.
25-羟基维生素D（25(OH)D）缺乏与1型自身免疫性糖尿病和多发性硬化症的易感性有关。我们的目的是评估血清25(OH)D水平与甲状腺自身免疫之间的关系。研究对象包括16至60岁的学生、教师和工作人员（共642人，男性244人，女性398人）。分别采用电化学发光法和放射免疫分析法测定血清游离甲状腺素、促甲状腺激素（TSH）、甲状腺过氧化物酶自身抗体（TPOAb）、完整甲状旁腺激素和25(OH)D。甲状腺功能障碍的定义为：（1）血清TSH≥5微单位/毫升且TPOAb>34国际单位/毫升，或（2）TSH≥10微单位/毫升但TPOAb正常。研究对象的血清25(OH)D平均水平为17.5（标准差10.2）纳摩尔/升，87%的人其值≤25纳摩尔/升。21%的研究对象TPOAb呈阳性。在控制和未控制年龄的情况下评估25(OH)D与TPOAb之间的关系，调整年龄后显示出显著的负相关（r = -0.08，P = 0.04）。根据血清25(OH)D分为≤25或>25纳摩尔/升两组或分为第一和第二三分位数进行分层的研究对象中，TPOAb和甲状腺功能障碍的患病率相当。血清25(OH)D值与TPOAb滴度仅呈微弱的负相关。这种微弱关联的存在以及血清25(OH)D范围较窄，使得我们无法根据血清25(OH)D的定量临界值来解释当前结果。需要在血清25(OH)D水平范围更广的维生素D充足人群中进行进一步研究，以证实本研究的结果。
