Czarnywojtek Agata, Florek Ewa, Pietrończyk Krzysztof, Sawicka-Gutaj Nadia, Ruchała Marek, Ronen Ohad, Nixon Iain J, Shaha Ashok R, Rodrigo Juan Pablo, Tufano Ralph Patrick, Zafereo Mark, Randolph Gregory William, Ferlito Alfio
Department of Pharmacology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
J Clin Med. 2023 Feb 11;12(4):1452. doi: 10.3390/jcm12041452.
Vitamin D (VitD) deficiency has garnered significant attention in contemporary medical research. Although the canonical biological activity of VitD manifests itself mainly in the regulation of calcium-phosphorus metabolism, recent studies show that, thanks to the presence of numerous receptors, VitD may also play an important role in regulating the immune system. VitD deficiency has been demonstrated to impact autoimmune disease, coeliac disease, infections (including respiratory/COVID-19), and patients with cancer. Recent studies also show that VitD plays a significant role in autoimmune thyroid diseases (AITDs). Many studies have shown a correlation between low VitD levels and chronic autoimmune thyroiditis - Hashimoto thyroiditis (HT), Graves' disease (GD), and postpartum thyroiditis (PPT). This review article, therefore, describes the current state of knowledge on the role of VitD in AITDs, including HT, GD, and PTT.
维生素D（VitD）缺乏在当代医学研究中已受到广泛关注。尽管VitD的经典生物学活性主要表现在钙磷代谢的调节上，但最近的研究表明，由于存在大量受体，VitD在调节免疫系统方面也可能发挥重要作用。VitD缺乏已被证明会影响自身免疫性疾病、乳糜泻、感染（包括呼吸道感染/新冠病毒感染）以及癌症患者。最近的研究还表明，VitD在自身免疫性甲状腺疾病（AITD）中起重要作用。许多研究表明，低VitD水平与慢性自身免疫性甲状腺炎——桥本甲状腺炎（HT）、格雷夫斯病（GD）和产后甲状腺炎（PPT）之间存在关联。因此，这篇综述文章描述了目前关于VitD在AITD（包括HT、GD和PTT）中作用的知识现状。
