• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

流感病毒之谜。

The influenza virus enigma.

作者信息

Salomon Rachelle, Webster Robert G

机构信息

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105-2678, USA.

出版信息

Cell. 2009 Feb 6;136(3):402-10. doi: 10.1016/j.cell.2009.01.029.

DOI:10.1016/j.cell.2009.01.029
PMID:19203576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2971533/
Abstract

Both seasonal and pandemic influenza continue to challenge both scientists and clinicians. Drug-resistant H1N1 influenza viruses have dominated the 2009 flu season, and the H5N1 avian influenza virus continues to kill both people and poultry in Eurasia. Here, we discuss the pathogenesis and transmissibility of influenza viruses and we emphasize the need to find better predictors of both seasonal and potentially pandemic influenza.

摘要

季节性流感和大流行性流感仍然对科学家和临床医生构成挑战。耐药性H1N1流感病毒在2009年流感季节占据主导地位,而H5N1禽流感病毒仍在欧亚大陆导致人和家禽死亡。在此,我们讨论流感病毒的发病机制和传播性,并强调需要找到更好的季节性流感和潜在大流行性流感的预测指标。

相似文献

1
The influenza virus enigma.流感病毒之谜。
Cell. 2009 Feb 6;136(3):402-10. doi: 10.1016/j.cell.2009.01.029.
2
Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness.人畜共患流感病毒:抗原和遗传特征以及用于大流行防范的候选疫苗病毒的研发
Wkly Epidemiol Rec. 2016 Mar 18;91(11):133-43.
3
Recommended composition of influenza virus vaccines for use in the 2017 southern hemisphere influenza season.2017年南半球流感季节使用的流感病毒疫苗推荐成分。
Wkly Epidemiol Rec. 2016 Oct 14;91(41):469-84.
4
Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness.人畜共患流感病毒:抗原和遗传特征以及大流行防范候选疫苗病毒的研发
Wkly Epidemiol Rec. 2017 Mar 24;92(12):129-44.
5
Low-dose interferon Type I treatment is effective against H5N1 and swine-origin H1N1 influenza A viruses in vitro and in vivo.低剂量Ⅰ型干扰素治疗对体外和体内的 H5N1 和猪源 H1N1 甲型流感病毒有效。
J Interferon Cytokine Res. 2011 Jun;31(6):515-25. doi: 10.1089/jir.2010.0071. Epub 2011 Feb 16.
6
Host species barriers to influenza virus infections.流感病毒感染的宿主物种屏障。
Science. 2006 Apr 21;312(5772):394-7. doi: 10.1126/science.1122818.
7
[Avian influenza, the hen, the man and the presumed death].[禽流感、母鸡、人类与假定的死亡]
Lakartidningen. 2007;104(32-33):2240-3.
8
Avian influenza aided readiness for swine flu.禽流感有助于为应对猪流感做好准备。
Nature. 2009 Jun 11;459(7248):756-7. doi: 10.1038/459756a.
9
Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness.人畜共患流感病毒的抗原和基因特征以及大流行防范候选疫苗病毒的研发。
Wkly Epidemiol Rec. 2015 Mar 20;90(12):109-20.
10
Vaccination with Recombinant Parainfluenza Virus 5 Expressing Neuraminidase Protects against Homologous and Heterologous Influenza Virus Challenge.接种表达神经氨酸酶的重组副流感病毒5可抵御同源和异源流感病毒攻击。
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.01579-17. Print 2017 Dec 1.

引用本文的文献

1
Restriction of influenza A virus replication by host DCAF7-CRL4B axis.宿主DCAF7-CRL4B轴对甲型流感病毒复制的限制
J Virol. 2025 Apr 15;99(4):e0013325. doi: 10.1128/jvi.00133-25. Epub 2025 Mar 27.
2
H5N1 influenza A virus: lessons from past outbreaks and emerging threats.H5N1甲型流感病毒:过去疫情的教训与新出现的威胁
Infez Med. 2025 Mar 1;33(1):76-89. doi: 10.53854/liim-3301-7. eCollection 2025.
3
Influenza A Viruses in the Swine Population: Ecology and Geographical Distribution.猪群中的甲型流感病毒:生态与地理分布。
Viruses. 2024 Nov 1;16(11):1728. doi: 10.3390/v16111728.
4
Plant resources for immunonutrients and immunomodulators to combat infectious respiratory viral diseases: a review.用于对抗传染性呼吸道病毒性疾病的免疫营养物和免疫调节剂的植物资源:综述
3 Biotech. 2024 Dec;14(12):302. doi: 10.1007/s13205-024-04143-y. Epub 2024 Nov 16.
5
Receptors and Host Factors for Enterovirus Infection: Implications for Cancer Therapy.肠道病毒感染的受体与宿主因素:对癌症治疗的启示
Cancers (Basel). 2024 Sep 12;16(18):3139. doi: 10.3390/cancers16183139.
6
A new antigen test device for rapid influenza A and B detection.一种用于快速检测甲型和乙型流感的新型抗原检测装置。
Heliyon. 2024 Jul 2;10(13):e33979. doi: 10.1016/j.heliyon.2024.e33979. eCollection 2024 Jul 15.
7
Rational Design of Novel Peptidomimetics against Influenza A Virus: Biological and Computational Studies.新型抗甲型流感病毒肽拟物的合理设计:生物学和计算研究。
Int J Mol Sci. 2023 Sep 19;24(18):14268. doi: 10.3390/ijms241814268.
8
Advances in the Relationship between Respiratory Viruses and Asthma.呼吸道病毒与哮喘关系的研究进展
J Clin Med. 2023 Aug 24;12(17):5501. doi: 10.3390/jcm12175501.
9
Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections.用于病毒感染诊断、治疗及改善疾病管理的代谢组学方法
Metabolites. 2023 Aug 15;13(8):948. doi: 10.3390/metabo13080948.
10
Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy.利用 I 型干扰素驱动的筛选策略鉴定抗流感 A 化合物抑制病毒非结构蛋白 1(NS1)。
Int J Mol Sci. 2023 Jun 22;24(13):10495. doi: 10.3390/ijms241310495.

本文引用的文献

1
Structural basis for suppression of a host antiviral response by influenza A virus.甲型流感病毒抑制宿主抗病毒反应的结构基础
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13093-8. doi: 10.1073/pnas.0805213105. Epub 2008 Aug 25.
2
Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness.细菌性肺炎在大流行性流感致死原因中占主要作用:对大流行性流感防范的启示
J Infect Dis. 2008 Oct 1;198(7):962-70. doi: 10.1086/591708.
3
Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets.雪貂感染致死性H5N1病毒期间宿主固有免疫反应的基因表达分析
J Virol. 2008 Nov;82(22):11308-17. doi: 10.1128/JVI.00691-08. Epub 2008 Aug 6.
4
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus.来自禽流感H5N1病毒的聚合酶PA(C)-PB1(N)复合物的晶体结构。
Nature. 2008 Aug 28;454(7208):1123-6. doi: 10.1038/nature07120. Epub 2008 Jul 9.
5
Drosophila RNAi screen identifies host genes important for influenza virus replication.果蝇RNA干扰筛选鉴定出对流感病毒复制重要的宿主基因。
Nature. 2008 Aug 14;454(7206):890-3. doi: 10.1038/nature07151. Epub 2008 Jul 9.
6
The evolutionary genetics and emergence of avian influenza viruses in wild birds.野生鸟类中禽流感病毒的进化遗传学与出现
PLoS Pathog. 2008 May 30;4(5):e1000076. doi: 10.1371/journal.ppat.1000076.
7
Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe.欧洲甲型H1N1流感病毒对奥司他韦耐药性的出现。
Euro Surveill. 2008 Jan 31;13(5):8026. doi: 10.2807/ese.13.05.08026-en.
8
Identification of the progenitors of Indonesian and Vietnamese avian influenza A (H5N1) viruses from southern China.源自中国南方的印度尼西亚和越南甲型禽流感(H5N1)病毒的祖源鉴定。
J Virol. 2008 Apr;82(7):3405-14. doi: 10.1128/JVI.02468-07. Epub 2008 Jan 23.
9
Novel approach to the development of effective H5N1 influenza A virus vaccines: use of M2 cytoplasmic tail mutants.开发有效的甲型H5N1流感病毒疫苗的新方法:使用M2细胞质尾突变体。
J Virol. 2008 Mar;82(5):2486-92. doi: 10.1128/JVI.01899-07. Epub 2007 Dec 26.
10
Identification of H2N3 influenza A viruses from swine in the United States.在美国猪群中鉴定出H2N3甲型流感病毒。
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20949-54. doi: 10.1073/pnas.0710286104. Epub 2007 Dec 18.