Mofaddel N, Krajian H, Villemin D, Desbène P L
L.A.S.O.C. - IRCOF et IFRMP, Université de Rouen, 55 rue Saint Germain, 27000 Evreux, France.
Talanta. 2009 Apr 30;78(2):631-7. doi: 10.1016/j.talanta.2008.12.027. Epub 2008 Dec 24.
A simple model for the separation of atropisomers of binaphthol and its monoderivatives by means of cyclodextrin-modified capillary zone electrophoresis (CD-CZE) was used to describe the migration behavior of poly charged enantiomers in a chiral separation system. This mathematical approach allowed for the determination of the optimal cyclodextrin concentrations for the enantioseparation of binaphthols by taking into account the influence of the formed complex mobilities. Moreover, using this theoretical approach, the reversal of the enantiomers' migration order as a function of cyclodextrin concentration was predicated. The apparent complexation constants between the cyclodextrins and the binaphthol and its monoderivatives could be calculated using a non-linear curve fitting method and three linear plotting methods (x-reciprocal, y-reciprocal and double reciprocal). Good agreements between the theoretical and experimental cyclodextrin concentrations were obtained.
采用一种通过环糊精修饰的毛细管区带电泳（CD - CZE）分离联萘酚及其单衍生物非对映异构体的简单模型，来描述多电荷对映体在手性分离系统中的迁移行为。这种数学方法通过考虑形成的复合物迁移率的影响，能够确定联萘酚对映体分离的最佳环糊精浓度。此外，使用这种理论方法，可以预测对映体迁移顺序随环糊精浓度的变化。环糊精与联萘酚及其单衍生物之间的表观络合常数可以使用非线性曲线拟合方法和三种线性绘图方法（x倒数、y倒数和双倒数）来计算。理论和实验得到的环糊精浓度之间具有良好的一致性。
