Baskin G B
Department of Pathology, Delta Regional Primate Research Center, Tulane University, Covington, LA 70433.
J Med Primatol. 1991 Jul;20(5):251-3.
Disseminated histoplasmosis due to Histoplasma capsulatum was diagnosed in a rhesus monkey inoculated with simian immunodeficiency virus (SIV). Immunohistochemical staining of tissues for viral core antigens revealed that those macrophages that expressed viral antigen contained few or no fungal organisms, while those that were filled with fungal organisms did not express viral antigen. This is a previously undocumented condition in a SIV-infected macaque, and suggests that SIV infection of individual macrophages is not the cause of macrophage dysfunction in SIV infections.
在一只接种了猿猴免疫缺陷病毒（SIV）的恒河猴中诊断出由荚膜组织胞浆菌引起的播散性组织胞浆菌病。对组织进行病毒核心抗原的免疫组织化学染色显示，那些表达病毒抗原的巨噬细胞含有很少或没有真菌生物体，而那些充满真菌生物体的巨噬细胞则不表达病毒抗原。这是在感染SIV的猕猴中以前未记录的情况，表明单个巨噬细胞的SIV感染不是SIV感染中巨噬细胞功能障碍的原因。
