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基于细菌视紫红质薄膜的生物电子成像阵列。

Bioelectronic imaging array based on bacteriorhodopsin film.

作者信息

Wang Wei Wei, Knopf George K, Bassi Amarjeet S

机构信息

University of Western Ontario, London, ON N6A 5B9 Canada.

出版信息

IEEE Trans Nanobioscience. 2008 Dec;7(4):249-56. doi: 10.1109/TNB.2008.2011851.

Abstract

A photoreceptor array that exploits the light sensitive bacteriorhodopsin (bR) films has been manufactured on a flexible indium-tin-oxide (ITO) coated plastic film using electrophoretic sedimentation technique (EPS). The effective sensing area of each photoreceptor is 2 x 2 mm (2), separated by 1 mm and arranged in a 4 x 4 array. A switched integrator with gain on the order of 10(10) is used to amplify the signal to a suitable level. When exposed to light, the differential response characteristic is attributed to charge displacement and recombination within bR molecules, as well as loading effects of the attached amplifier. The peak spectral response occurs at 568 nm and is linear over the tested light power range of 200 mu W to 12 mW. The response remains linear at other tested wavelengths, but with reduced amplitude. Initial tests have indicated that responsivity among all photoreceptors is greater than 71% of the average value, 465.25 mV/mW. The differential nature of the signal generated by bR makes it a suitable sensing material for vision applications such as motion detection. The prototype array demonstrates this property by employing Reichardt's delay-and-correlate algorithm. Furthermore, fabricating sensor arrays on flexible substrates introduces a new design approach that enables non-planar imaging surfaces.

摘要

一种利用光敏感细菌视紫红质(bR)薄膜的光感受器阵列,已采用电泳沉积技术(EPS)在涂覆有柔性氧化铟锡(ITO)的塑料薄膜上制造而成。每个光感受器的有效传感面积为2×2平方毫米,间隔为1毫米,并排列成4×4阵列。使用增益约为10的10次方的开关积分器将信号放大到合适水平。当暴露于光线下时,差分响应特性归因于bR分子内的电荷位移和复合,以及所连接放大器的负载效应。峰值光谱响应出现在568纳米处,并且在200微瓦至12毫瓦的测试光功率范围内呈线性。在其他测试波长下响应仍保持线性,但幅度减小。初步测试表明,所有光感受器的响应度大于平均值465.25毫伏/毫瓦的71%。bR产生的信号的差分特性使其成为适用于诸如运动检测等视觉应用的传感材料。该原型阵列通过采用赖夏特延迟相关算法展示了这一特性。此外,在柔性基板上制造传感器阵列引入了一种新的设计方法,可实现非平面成像表面。

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