人类免疫缺陷病毒相关感觉神经病变研究诊断的简化
Simplification of the research diagnosis of HIV-associated sensory neuropathy.
作者信息
Evans Scott R, Clifford David B, Kitch Douglas W, Goodkin Karl, Schifitto Giovanni, McArthur Justin C, Simpson David M
机构信息
Harvard School of Public Health, Boston, Massachusetts 02115, USA.
出版信息
HIV Clin Trials. 2008 Nov-Dec;9(6):434-9. doi: 10.1310/hct0906-434.
Abstract
Peripheral neuropathy (PN) is the most common neurological complication of HIV infection,affecting over one third of patients. The research diagnosis of PN is complicated by the need for expensive, time-consuming, and noxious diagnostic tests. We investigated whether nerve conduction studies (NSC) and quantitative sensory tests (QST) provide added value for the diagnosis of PN for research purposes or whether the easily obtainable clinical measures (sensory and motor symptoms, sensitivity to pain and vibration, tendon reflexes, motor function) are sufficient.
摘要
周围神经病变（PN）是HIV感染最常见的神经并发症，影响超过三分之一的患者。PN的研究诊断因需要昂贵、耗时且有害的诊断测试而变得复杂。我们研究了神经传导研究（NSC）和定量感觉测试（QST）对于PN研究诊断是否具有附加价值，或者易于获得的临床指标（感觉和运动症状、对疼痛和振动的敏感性、腱反射、运动功能）是否足够。
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本文引用的文献
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J Neuropathol Exp Neurol. 2007 Dec;66(12):1059-73. doi: 10.1097/nen.0b013e31815c8989.
2
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J Acquir Immune Defic Syndr. 2008 Jan 1;47(1):27-35. doi: 10.1097/QAI.0b013e31815acacc.
3
Prevalence of and risk factors for HIV-associated neuropathy in Melbourne, Australia 1993-2006.1993 - 2006年澳大利亚墨尔本地区与HIV相关神经病变的患病率及危险因素
HIV Med. 2007 Sep;8(6):367-73. doi: 10.1111/j.1468-1293.2007.00478.x.
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