Otsuka M, Konishi S, Takahashi T, Saito K
Adv Biochem Psychopharmacol. 1976;15:187-91.
Substance P has a powerful excitant action on spinal motoneurons of the newborn rat, and the action is specifically antagonized by Lioresal, which also readily blocks spinal reflexes involving primary afferent transmission. Substance P is highly concentrated in bovine and feline dorsal roots as well as in the dorsal part of the dorsal horn of cat spinal cord. There is evidence that substance P is synthesized in spinal ganglia, transported through the dorsal roots and stored in the axon terminals of primary afferent neurons. These and other results suggest that the undecapeptide substance P, or one of its shorter C-terminal analogues, functions as an excitatory transmitter of the primary afferent fibers.
P物质对新生大鼠的脊髓运动神经元具有强大的兴奋作用，且该作用可被氯苯氨丁酸特异性拮抗，氯苯氨丁酸也能轻易阻断涉及初级传入神经传递的脊髓反射。P物质高度集中于牛和猫的背根以及猫脊髓背角的背侧部分。有证据表明，P物质在脊髓神经节中合成，通过背根运输并储存于初级传入神经元的轴突终末。这些以及其他结果表明，十一肽P物质或其较短的C末端类似物之一，作为初级传入纤维的兴奋性递质发挥作用。
