ω-芳氧基和芳氨基连接的α,β-不饱和醛的催化不对称分子内氢芳基化反应
Catalytic asymmetric intramolecular hydroarylations of omega-aryloxy- and arylamino-tethered alpha,beta-unsaturated aldehydes.
作者信息
Lu Hai-Hua, Liu Hui, Wu Wei, Wang Xu-Fan, Lu Liang-Qiu, Xiao Wen-Jing
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
出版信息
Chemistry. 2009;15(12):2742-6. doi: 10.1002/chem.200802722.
PMID:19204966
Abstract
Economical approach: The first organocatalytic asymmetric intramolecular hydroarylation of phenol- and aniline-derived enals offers one of the most straightforward and atom-economic approaches to enantioriched chromans and tetrahydroquinolines (up to 96% ee; see scheme).
摘要
经济方法
苯酚和苯胺衍生的烯醛的首次有机催化不对称分子内氢芳基化反应，为对映体富集的色满和四氢喹啉提供了最直接且原子经济的方法之一（对映体过量高达96%；见方案）。
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