Laboratory of Heterogeneous Catalysis, Institute of Nanochemistry and Catalysis, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary.
Chirality. 2010 Jan;22(1):3-15. doi: 10.1002/chir.20694.
The enantioselective hydrogenation of methyl or ethyl pyruvate over cinchona-platinum catalyst system (Orito's reaction) is one of the most intensively studied heterogeneous catalytic asymmetric hydrogenation reactions. Studies aiming at systematic changes of the chiral template have played a crucial role in creating hypotheses for the mechanism of Orito's reaction. It is very important to clarify which structural unit of the alkaloid takes part in the enantiodifferentiation, and learn about the role of the different structural units of chiral templates. In this article, we made an attempt to describe the behavior of natural alkaloids, their synthetic derivatives, and analogues as chiral templates in the heterogeneous catalytic asymmetric hydrogenation of activated ketones.
手性钌催化剂催化的酮的不对称氢化反应是近年来不对称合成领域的研究热点之一。我们对一系列天然手性小分子作为手性配体应用于酮的不对称氢化反应进行了研究，探讨了它们的结构与催化性能之间的关系。
