Adekile A D, Reindorf C A, Adeodu O A, Johnson W, Dairo B A
Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Natl Med Assoc. 1991 Apr;83(4):329-31.
Using direct interference phase-contrast microscopy (Normansky Optics), pit counts were performed on 32 HbSS patients, aged 3 to 17 years. The influence of age and splenic size on counts were also investigated. Nine HbSS and 15 HbAA age and sex-matched, healthy individuals served as controls. The mean +/- SD counts in the three groups were 11.1 +/- 9.1%, 1.7 +/- 1.4% and 1.8 +/- 1.7%, respectively. The older SS patients tended to have higher values, but the linear correlation with age was not impressive (r = 0.28). Seventeen (53.1%) patients had counts greater than 10%, while 8 (25%) had less than 3.5%. Five patients with gross splenomegaly had a mean count of 4.3 +/- 1.9%, significantly lower than the figure of 12.3 +/- 7.9% for the patients without splenomegaly (P less than .001), demonstrating retained reticulo-endothelial function in such patients.
使用直接干涉相差显微镜（诺马斯基光学系统），对32名年龄在3至17岁的HbSS患者进行了凹坑计数。同时还研究了年龄和脾脏大小对计数的影响。选取9名年龄和性别匹配的HbSS患者以及15名年龄和性别匹配的健康HbAA个体作为对照。三组的平均计数±标准差分别为11.1±9.1%、1.7±1.4%和1.8±1.7%。年龄较大的SS患者计数往往较高，但与年龄的线性相关性并不显著（r = 0.28）。17名（53.1%）患者的计数大于10%，而8名（25%）患者的计数小于3.5%。5名脾脏明显肿大的患者平均计数为4.3±1.9%，显著低于无脾脏肿大患者的12.3±7.9%（P＜0.001），表明此类患者保留了网状内皮功能。
