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体内多巴胺能机制对大鼠小脑环磷酸鸟苷的影响。

Changes of rat cerebellar guanosine 3',5'-cyclic phosphate by dopaminergic mechanisms in vivo.

作者信息

Burkard W P, Pieri L, Haefely W

出版信息

Adv Biochem Psychopharmacol. 1976;15:315-24.

PMID:192051
Abstract

Apomorphine produced a dose-dependent increase of the cGMP level in the cerebellum. Haloperidol and scopolamine completely prevented this increase, and reserpine reduced the increase to 50%. LSD elevated cerebellar cGMP, and this effect was also abolished by haloperidol. It is suggested that the primary site of action of these drugs is the caudate nucleus, from which two neuronal pathways could trigger the increase of cGMP in the cerebellum.

摘要

阿扑吗啡使小脑内的环磷酸鸟苷（cGMP）水平呈剂量依赖性升高。氟哌啶醇和东莨菪碱完全抑制了这种升高，而利血平则将这种升高降低至50%。麦角酸二乙胺（LSD）使小脑cGMP升高，氟哌啶醇也消除了这种作用。提示这些药物的主要作用部位是尾状核，从尾状核发出的两条神经通路可触发小脑中cGMP的升高。

相似文献

1
Changes of rat cerebellar guanosine 3',5'-cyclic phosphate by dopaminergic mechanisms in vivo.体内多巴胺能机制对大鼠小脑环磷酸鸟苷的影响。
Adv Biochem Psychopharmacol. 1976;15:315-24.
2
In vivo changes of guanosine 3',5'-cyclic phosphate in rat cerebellum by dopaminergic mechanisms.
J Neurochem. 1976 Jul;27(1):297-8. doi: 10.1111/j.1471-4159.1976.tb01581.x.
3
Pharmacologically induced changes in the 3':5'-cyclic guanosine monophosphate content of rat cerebellar cortex: difference between apomorphine, haloperidol and harmaline.药物诱导大鼠小脑皮质3':5'-环磷酸鸟苷含量的变化：阿扑吗啡、氟哌啶醇和骆驼蓬碱之间的差异
J Pharmacol Exp Ther. 1977 Jan;200(1):207-15.
4
Different mechanisms mediating the decrease of cerebellar cGMP elicited by haloperidol and diazepam.介导氟哌啶醇和地西泮引起小脑环磷酸鸟苷（cGMP）减少的不同机制。
Adv Biochem Psychopharmacol. 1976;15:325-35.
5
Scopolamine-induced hypermotility in rats is mediated via a dopaminergic system.
Acta Biol Med Ger. 1980;39(8-9):903-10.
6
Effect of dopaminergic agonists and antagonists on in vivo cyclic nucleotide content: relation of guanosine 3':5'- monophosphate (cGMP) changes in cerebellum to behavior.多巴胺能激动剂和拮抗剂对体内环核苷酸含量的影响：小脑鸟苷 3':5'-单磷酸（cGMP）变化与行为的关系。
J Pharmacol Exp Ther. 1979 May;209(2):262-70.
7
Striato-cerebellar pathway controlling cyclic GMP content in the cerebellum: role of dopamine, GABA and enkephalins.控制小脑中环鸟苷酸含量的纹状体-小脑通路：多巴胺、γ-氨基丁酸和脑啡肽的作用。
Adv Biochem Psychopharmacol. 1978;18:227-44.
8
Change in brain guanosine 3',5'-monophosphate (cGMP) content by thyrotropin-releasing hormone.促甲状腺激素释放激素对脑鸟苷 3',5'-单磷酸（环磷酸鸟苷，cGMP）含量的影响
J Pharmacol Exp Ther. 1979 Feb;208(2):169-75.
9
Cyclic AMP in retina and caudate nucleus: influence of dopamine and other agents.视网膜和尾状核中的环磷酸腺苷：多巴胺及其他因子的影响
Adv Cyclic Nucleotide Res. 1975;5:661-79.
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Kainic acid-induced lesion of dopaminergic target cells in the striatum: consequences on the dynamics of cerebellar cGMP.海人酸诱导的纹状体中多巴胺能靶细胞损伤：对小脑环磷酸鸟苷动力学的影响
Naunyn Schmiedebergs Arch Pharmacol. 1978 Aug;304(1):5-7. doi: 10.1007/BF00501370.

引用本文的文献

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Regression of cerebellar syndrome with long-term administration of 5-HTP or the combination 5-HTP-benserazide.长期服用5-羟色氨酸（5-HTP）或5-羟色氨酸与苄丝肼的组合后小脑综合征的消退。
Ital J Neurol Sci. 1984 Sep;5(3):253-66. doi: 10.1007/BF02043955.
2
Kainic acid-induced lesion of dopaminergic target cells in the striatum: consequences on the dynamics of cerebellar cGMP.海人酸诱导的纹状体中多巴胺能靶细胞损伤：对小脑环磷酸鸟苷动力学的影响
Naunyn Schmiedebergs Arch Pharmacol. 1978 Aug;304(1):5-7. doi: 10.1007/BF00501370.