Bossé Ynuk, Stankova Jana, Rola-Pleszczynski Marek
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Health Care/St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Ann Allergy Asthma Immunol. 2009 Jan;102(1):16-21. doi: 10.1016/S1081-1206(10)60102-0.
To present a historic perspective and an up-to-date understanding of the involvement of cysteinyl-leukotrienes (cys-LTs) in asthmatic airway smooth muscle (ASM) cell hyperplasia.
Data collected from human tissues, from animal models of airway inflammation, and from ASM cells cultured in vitro are included.
All studies regarding the potential contribution of cys-LTs on ASM cell hyperplasia are reviewed.
Whereas in vivo observations are consistent and seem to attribute an important role for cys-LTs in ASM cell hyperplasia, the observations made in cultured ASM cells are inconsistent, with studies documenting a mitogenic potential only reporting marginal effects.
This dichotomy between in vitro and in vivo results led to the elaboration of a hypothesis suggesting that the mitogenic effect of cys-LTs on ASM cells may be indirect and mediated by a paracrine loop involving transforming growth factor beta1 production by airway resident and inflammatory cells.
阐述对半胱氨酰白三烯（cys-LTs）参与哮喘气道平滑肌（ASM）细胞增生的历史观点及最新认识。
包括从人体组织、气道炎症动物模型以及体外培养的ASM细胞收集的数据。
回顾了所有关于cys-LTs对ASM细胞增生潜在作用的研究。
体内观察结果一致，似乎表明cys-LTs在ASM细胞增生中起重要作用，而体外培养的ASM细胞的观察结果不一致，记录有促有丝分裂潜能的研究仅报告了轻微作用。
体外和体内结果的这种二分法促使提出一个假说，即cys-LTs对ASM细胞的促有丝分裂作用可能是间接的，由一个旁分泌环介导，该旁分泌环涉及气道驻留细胞和炎症细胞产生转化生长因子β1。
