Odo M O, Bisong S A, Akpa O A, Udokang A, Obidua C I, Ekanem T B, Osim E E
Department of Anatomy, University of Calabar, P. M. B. 1115, Calabar 540001, Nigeria.
Afr J Med Med Sci. 2007 Jun;36(2):119-23.
The neurobehavioural patterns in the open field following oral artesunate administration was studied using 40 albino rats randomly assigned to three Groups, namely A, B and C. Prior to the test, all the animals were acclimatized for 5 minutes in the open field maze. Group A (8 males and 8 females) received therapeutic doses of artesunate (1.42 mg/kg per oral (p.o.)--using oro-gastric tubes while Group B (8 males and 8 females) received pharmacological doses of 4.26 mg/kg (p.o.). Group C served as the control and were administered only distilled water (p.o.). Gross behavioural changes were noted following the therapeutic and pharmacological administration of artesunate for five days. Rats in Groups A and B showed marked decrease in loco motor activity (line crossing) and exploratory (rearing and walling) activities in comparison with the control (P<0.05). The centre square activity was significantly decreased in Groups A and B in comparison with the control (P<0.01). The number of faecal boli and urine puddles did not change significantly in Groups A and B when compared with the control (P>0.05). However, the frequency of grooming was significantly lower in Groups A and B rats than in the control (P<0.01). The frequency and duration of freezing were significantly higher in Groups A and B rats than in the control rats (P<0.01). There were no significant differences between the values for the male and female rats. There was also no dose dependent effect of artesunate on the activities studied. Oral administration of artesunate significantly decreases loco motor and exploratory behaviours in the albino rat.
使用40只白化大鼠进行研究，这些大鼠被随机分为A、B和C三组，以观察口服青蒿琥酯后在旷场中的神经行为模式。在测试前，所有动物在旷场迷宫中适应5分钟。A组（8只雄性和8只雌性）接受治疗剂量的青蒿琥酯（1.42毫克/千克口服（经口）——使用胃管），而B组（8只雄性和8只雌性）接受4.26毫克/千克的药理剂量（经口）。C组作为对照组，仅给予蒸馏水（经口）。在给予青蒿琥酯治疗和药理剂量五天后，记录明显的行为变化。与对照组相比，A组和B组大鼠的运动活动（穿越直线）和探索活动（直立和靠墙）明显减少（P<0.05）。与对照组相比，A组和B组的中央方格活动明显减少（P<0.01）。与对照组相比，A组和B组的粪便颗粒和尿坑数量没有显著变化（P>0.05）。然而，A组和B组大鼠的梳理频率明显低于对照组（P<0.01）。A组和B组大鼠的僵住频率和持续时间明显高于对照组大鼠（P<0.01）。雄性和雌性大鼠的值之间没有显著差异。青蒿琥酯对所研究的活动也没有剂量依赖性影响。口服青蒿琥酯显著降低白化大鼠的运动和探索行为。
