Wang T Y, Hussey C V, Garancis J C
Am J Clin Pathol. 1977 Apr;67(4):362-7. doi: 10.1093/ajcp/67.4.362.
Prostaglandin E1 (PGE1) exerted an immediate inhibitory effect upon the induction of platelet aggregation by adenosinediphosphate, epinephrine, thrombin, bovine fibrinogen, or sodium fluoride, whereas dibutyryl cyclic adenosinemonophosphate (DBcAMP) produced a delayed type of inhibition of aggregation induced by these same agents. In addition, however, both PGE1 and DBcAMP, as well as adenosinetriphosphate (ATP) and Mg++, restored, with incubation, the washed platelets to a more discoid shape. Platelet aggregability also correlated well with platelet shape. All of these findings suggest the possibility of mediation of the delayed type of inhibition through restoration of the platelet membrane by increasing the level of metabolically active ATP or the availability of cations. They tend, however, to exclude the possibility that PGE1 exerts its immediate inhibitory effect through the increase of platelet cAMP.
前列腺素E1（PGE1）对二磷酸腺苷、肾上腺素、凝血酶、牛纤维蛋白原或氟化钠诱导的血小板聚集产生即时抑制作用，而二丁酰环磷酸腺苷（DBcAMP）对这些相同试剂诱导的聚集产生延迟性抑制。然而，此外，PGE1和DBcAMP以及三磷酸腺苷（ATP）和镁离子在孵育时可使洗涤后的血小板恢复为更盘状的形状。血小板聚集性也与血小板形状密切相关。所有这些发现表明，通过提高代谢活性ATP水平或阳离子的可用性来恢复血小板膜，可能介导延迟性抑制。然而，这些发现倾向于排除PGE1通过增加血小板环磷酸腺苷发挥其即时抑制作用的可能性。
