Nadeem Amina, Aslam Muhammad, Khan Dilshad Ahmad, Hussain Tassawar, Khan Saadat Ali
Department of Physiology, Army Medical College, Rawalpindi.
J Coll Physicians Surg Pak. 2009 Feb;19(2):86-9.
To determine the frequency of thyroid dysfunction in patients of chronic hepatitis C during treatment with interferon alpha-2b and ribavirin therapy.
A cohort study.
Army Medical College and Military Hospital, Rawalpindi, from February 2006 to January 2007.
One hundred and sixty seven non-cirrhotic chronic hepatitis C patients were grouped into treatment group (n=107) and control group (n=60) awaiting treatment. Baseline serum(s.) Alanine Transferase (ALT) and S. Aspartate Transferase (AST) were measured by IFCC method. Serum Thyroid Stimulating Hormone (S. TSH), serum free thyroxine (S. Free T4) and serum total triiodothyronine (S.T3) level were determined by chemiluminescence. Study group patients underwent 24 weeks IFN and ribavirin therapy and were followed-up for thyroid dysfunction at weeks 0, 12 and 24. Control group patients underwent the same tests at weeks 0, 12 and 24. Statistical analysis was done on SPSS 15.
Out of 107 patients of treatment group, 20 patients (18.69%) developed thyroid dysfunction. Females were at higher risk with Relative Risk (RR) of 11.25 and Attributable Risk (AR) of 91%. Hypothyroidism was more common than hyperthyroidism.
Interferon-alpha and ribavirin therapy induces thyroid dysfunction in chronic hepatitis C patients. Hypothyroidism was more common. Females are at a higher risk of developing thyroid dysfunction.
确定慢性丙型肝炎患者在接受α-2b干扰素和利巴韦林治疗期间甲状腺功能障碍的发生率。
队列研究。
2006年2月至2007年1月，拉瓦尔品第的陆军医学院和军事医院。
167例非肝硬化慢性丙型肝炎患者被分为治疗组（n = 107）和等待治疗的对照组（n = 60）。采用IFCC法测定基线血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）。通过化学发光法测定血清促甲状腺激素（S.TSH）、血清游离甲状腺素（S.Free T4）和血清总三碘甲状腺原氨酸（S.T3）水平。研究组患者接受24周的干扰素和利巴韦林治疗，并在第0、12和24周对甲状腺功能障碍进行随访。对照组患者在第0、12和24周进行相同的检测。使用SPSS 15进行统计分析。
治疗组的107例患者中，20例（18.69%）出现甲状腺功能障碍。女性风险更高，相对风险（RR）为11.25，归因风险（AR）为91%。甲状腺功能减退比甲状腺功能亢进更常见。
α-干扰素和利巴韦林治疗可导致慢性丙型肝炎患者出现甲状腺功能障碍。甲状腺功能减退更常见。女性发生甲状腺功能障碍的风险更高。
