[因子XIa-α1抗胰蛋白酶复合物]

[Factor XIa-alpha 1 antitrypsin complex].

作者信息

Egawa H, Komiyama Y, Nishikado H, Masuda M, Murakami T, Murata K

机构信息

Department of Clinico-Laboratory Medicine, Kansai Medical University, Moriguchi.

出版信息

Rinsho Byori. 1991 Jul;39(7):707-13.

PMID:1920863

Abstract

We developed a new rapid assay for the factor XIa-alpha 1 antitrypsin complex (FXIa-alpha 1AT) in plasma using an anti FXI monoclonal antibody (KMXI-1). In 20-fold diluted plasma samples, this assay was not affected by co-existing FXI or non specific color development of the plasma. Normal level of FXIa-alpha 1AT (11 +/- 4.1 ng/ml plasma) increased with the aging of healthy adults. The FXIa-alpha 1AT levels of patients with disseminated intravascular coagulation (DIC) rose along with the progression of the disease, and the appearance of high levels and the peak of FXIa-alpha 1AT developed faster than FDP-E or alpha 2plasmin inhibitor-plasmin complex (alpha 2PI-PmC) in most patients. These results indicate that, in addition of FDP and alpha 2PI-PmC, FXIa-alpha 1AT is a useful molecular marker for DIC.

摘要

我们使用抗因子XI单克隆抗体（KMXI-1）开发了一种用于检测血浆中因子XIa-α1抗胰蛋白酶复合物（FXIa-α1AT）的新型快速检测方法。在20倍稀释的血浆样本中，该检测不受共存的因子XI或血浆非特异性显色的影响。健康成年人血浆中FXIa-α1AT的正常水平（11±4.1 ng/ml血浆）随年龄增长而升高。弥散性血管内凝血（DIC）患者的FXIa-α1AT水平随疾病进展而升高，在大多数患者中，FXIa-α1AT高水平的出现和峰值比纤维蛋白降解产物E（FDP-E）或α2纤溶酶抑制剂-纤溶酶复合物（α2PI-PmC）出现得更快。这些结果表明，除了FDP和α2PI-PmC外，FXIa-α1AT也是DIC的一种有用分子标志物。