Maruta M, Takenaka K, Takabe H, Akiyama T, Obana Y, Furuta I, Ohba Y
Department of Central Clinical Laboratory, Kinki University Hospital, Osaka-sayama.
Rinsho Byori. 1991 Aug;39(8):824-8.
We examined immunological abnormalities in patients with dilated cardiomyopathy (DCM) and reviewed their medical histories, NYHA classifications, electrocardiogram findings and chest X-Ray findings with regard to severity of DCM. Elevated CD4/CD8 ratio as well as decreased number of CD8 cells in lymphocyte subsets was recognized. These abnormalities were particularly noted in patients with past history of myocarditis. NYHA IV class increases in CTR and left ventricular dimension, and a reduced ejection fraction. These findings suggest that lasting of myocardial damage causes immunological abnormalities and the examination of DCM patients' immunological status is useful in anticipating disease process and determining medical treatment.
我们检查了扩张型心肌病（DCM）患者的免疫异常情况，并回顾了他们的病史、纽约心脏协会（NYHA）分级、心电图结果以及胸部X光检查结果，以了解DCM的严重程度。我们发现淋巴细胞亚群中CD4/CD8比值升高以及CD8细胞数量减少。这些异常在有心肌炎病史的患者中尤为明显。NYHA IV级患者的心胸比率（CTR）和左心室尺寸增加，射血分数降低。这些发现表明，心肌损伤的持续会导致免疫异常，对DCM患者的免疫状态进行检查有助于预测疾病进程和确定治疗方案。
