Suga K, Ariyoshi I, Kuramitsu T, Nakanishi T, Utsumi H, Yamada N
Department of Radiology, Yamaguchi University School of Medicine.
Kaku Igaku. 1991 Jul;28(7):759-65.
To investigate the mechanism of intrapulmonary kinetics of N-isopropyl-p-123I-iodoamphetamine (123I-IMP), we performed lung scanning with 123I-IMP in 13 rabbits in which a unilateral bronchus was occluded by a balloon catheter. In 9 rabbits, on the delayed distribution images, an abnormal accumulation of 123I-IMP was detected in the hypoperfusion area of the peripheral lung field of the occluded bronchus, which was detected on lung perfusion images with 99mTc-MAA. Comparison of early (a summation image during 20 seconds immediately after injection) and delayed (a summation image from 70 to 90 minutes after injection) distribution images confirmed that during this period, 123I-IMP accumulated in the area of reduced distribution of 123I-IMP. Moreover, at the site of abnormal accumulation, washout of 123I-IMP from the lung was delayed compared with that in the normal lung field. We find this experimental study is similar to the results in 63 clinical cases, which we have reported previously, and confirm that pulmonary arterial perfusion, especially hypoperfusion, influences the intrapulmonary kinetics of 123I-IMP.
为研究N-异丙基-p-123I-碘安非他明（123I-IMP）的肺内动力学机制，我们对13只家兔进行了123I-IMP肺扫描，这些家兔的一侧支气管被球囊导管阻塞。在9只家兔中，在延迟分布图像上，在被阻塞支气管外周肺野的灌注减低区检测到123I-IMP异常蓄积，这一区域在99mTc-MAA肺灌注图像上也被检测到。早期（注射后立即20秒内的叠加图像）和延迟（注射后70至90分钟的叠加图像）分布图像的比较证实，在此期间，123I-IMP在123I-IMP分布减少的区域蓄积。此外，在异常蓄积部位，123I-IMP从肺内的洗脱比正常肺野延迟。我们发现这项实验研究与我们之前报道的63例临床病例结果相似，并证实肺动脉灌注，尤其是灌注减低，会影响123I-IMP的肺内动力学。
