Aciro Caroline, Davies Stephen G, Kurosawa Wataru, Roberts Paul M, Russell Angela J, Thomson James E
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Org Lett. 2009 Mar 19;11(6):1333-6. doi: 10.1021/ol900114b.
Oxidation of 3-N,N-dibenzylaminocyclohex-1-ene N-oxide in the presence of Cl3CCO2H proceeds with high levels of anti-diastereoselectivity (97% de), with no competing side reactions, allowing access to 1,2-anti-2,3-anti-3-aminocyclohexane-1,2-diol after deprotection.
在三氯乙酸存在下，3 - N，N - 二苄基氨基环己 - 1 - 烯N - 氧化物的氧化反应以高反式非对映选择性（97% 的非对映体过量）进行，且无竞争性副反应，脱保护后可得到1,2 - 反式 - 2,3 - 反式 - 3 - 氨基环己烷 - 1,2 - 二醇。
