Karron Ruth A, Callahan Karen, Luke Catherine, Thumar Bhagvanji, McAuliffe Josephine, Schappell Elizabeth, Joseph Tomy, Coelingh Kathleen, Jin Hong, Kemble George, Murphy Brian R, Subbarao Kanta
Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
J Infect Dis. 2009 Mar 1;199(5):711-6. doi: 10.1086/596558.
Development of live attenuated influenza vaccines (LAIV) against avian strains with pandemic potential is an important public-health strategy. Either 1 or 2 10(7)-TCID(50) doses of H9N2 LAIV A/chicken/Hong Kong/G9/97 were administered intranasally to 50 adults in isolation; 41 participants were H9N2 seronegative, 24 of whom received 2 doses. The vaccine was well tolerated; vaccine shedding was minimal. After 2 doses, 92% of H9-seronegative participants had > or = 4-fold increases in hemagglutination-inhibition antibody, and 79% had > or = 4-fold increases in neutralizing antibody; 100% had responses detected by at least 1 assay. Although replication of the H9N2 LAIV was restricted, 2 doses were immunogenic in H9N2-seronegative adults. Trial registration. ClinicalTrials.gov identifier: NCT00110279 .
研发针对具有大流行潜力的禽流感毒株的减毒活流感疫苗(LAIV)是一项重要的公共卫生策略。将1或2剂10⁷组织培养感染剂量(TCID₅₀)的H9N2 LAIV A/鸡/香港/G9/97经鼻内接种给50名隔离的成年人;41名参与者H9N2血清学阴性,其中24人接受了2剂疫苗。该疫苗耐受性良好;疫苗排出极少。接种2剂后,92%的H9血清学阴性参与者血凝抑制抗体增加≥4倍,79%的参与者中和抗体增加≥4倍;100%的参与者至少通过1种检测方法检测到有反应。尽管H9N2 LAIV的复制受到限制,但2剂疫苗对H9N2血清学阴性的成年人具有免疫原性。试验注册。ClinicalTrials.gov标识符:NCT00110279 。