Department of Physiology, Southern Illinois University, Carbondale, Illinois 62901-6503, USA.
J Neuroendocrinol. 1990 Apr 1;2(2):145-9. doi: 10.1111/j.1365-2826.1990.tb00844.x.
Abstract The responsiveness of prolactin release to regulatory inputs depends on the functional state of the lactotrophs. In the present study, we have examined the effects of luteinizing hormone-releasing hormone (LHRH; 10(-7) or 10(-6) M) on the release of prolactin in vitro from hyperplastic pituitaries of estrogen-treated male Fischer rats, ectopic pituitary transplants and in situ pituitaries of grafted and control rats. The effects of dopamine (10(-8) or 10(-7) M) in this system were also examined. The extent of inhibition of prolactin release by dopamine was not related to the amounts of prolactin secreted under basal conditions or to plasma prolactin levels. LHRH significantly suppressed prolactin secretion in all groups but its effect was most pronounced in the ectopic pituitary transplants and in the hyperplastic pituitaries of animals after chronic exposure to estrogen followed by a period of recovery. Thus, the effects of LHRH on prolactin release appear to be related to the secretory activity and/or to the absolute or relative number of the lactotrophs.
摘要 泌乳素释放对调节输入的反应性取决于催乳素细胞的功能状态。在本研究中，我们研究了黄体生成素释放激素 (LHRH；10(-7) 或 10(-6) M) 对雌激素处理的雄性 Fischer 大鼠、异位垂体移植和移植和对照大鼠原位垂体中增生性垂体泌乳素体外释放的影响。还检查了多巴胺 (10(-8) 或 10(-7) M) 在该系统中的作用。多巴胺对泌乳素释放的抑制程度与基础条件下泌乳素的分泌量或血浆泌乳素水平无关。LHRH 显著抑制所有组的泌乳素分泌，但在异位垂体移植和慢性暴露于雌激素后恢复期的动物增生性垂体中，其作用最为明显。因此，LHRH 对泌乳素释放的影响似乎与催乳素细胞的分泌活性和/或绝对或相对数量有关。
