Department of Medicine, Division of Nephrology and Hypertension, Tulane University, New Orleans, LA 70112-2632, USA.
Clin Transplant. 2009 Nov-Dec;23(6):848-52. doi: 10.1111/j.1399-0012.2009.00967.x. Epub 2009 Feb 5.
Myeloma kidney and myeloma-associated renal disorders including light chain deposition disease can occur as recurrent or de novo disease in renal allografts. These kidney disorders usually manifest with worsening allograft function and proteinuria. Identification of the precise cause of kidney disorder often requires kidney biopsy and demonstration of monoclonal light chains in the kidney. Here, we present an unusual case of light chain nephropathy in a living-related kidney transplant recipient involving light chain crystallization in the proximal tubule occurring within less than three months after transplant. The etiology of renal failure prior to transplant in our patient is not clear. To the best of our knowledge, the ultrastructural changes seen in our patient have not been described in literature previously. Our patient was treated with steroids, which resulted in short-term improvement in allograft dysfunction.
骨髓瘤肾和骨髓瘤相关的肾脏疾病，包括轻链沉积病，可在肾移植后作为复发性或新发疾病发生。这些肾脏疾病通常表现为移植物功能恶化和蛋白尿。确定肾脏疾病的确切原因通常需要肾活检和肾脏中单克隆轻链的显示。在这里，我们提出了一个不常见的活相关肾移植受者的轻链肾病的病例，涉及移植后不到 3 个月近端小管内轻链结晶。我们患者移植前肾功能衰竭的病因尚不清楚。据我们所知，我们患者的超微结构改变以前在文献中没有描述过。我们的患者接受了类固醇治疗，这导致移植物功能障碍的短期改善。
