Pei Jin-Jing, Hugon Jacques
Karolinska Institute, Department of Neurobiology, Care Sciences and Society, KI-ADRC, Stockholm, Sweden.
J Cell Mol Med. 2008 Dec;12(6B):2525-32. doi: 10.1111/j.1582-4934.2008.00509.x.
Neurodegeneration and neurofibrillary degeneration are the two main pathological mechanisms of cognitive impairments in Alzheimer's disease (AD). It is not clear what factors determine the fates of neurons during the progress of the disease. Emerging evidence has suggested that mTOR-dependent signalling is involved in the two types of degeneration in AD brains. This review focuses on the roles of mTOR-dependent signalling in the pathogenesis of AD. It summarizes the recent advancements in the understanding of its roles in neurodegeneration and neurofibrillary degeneration, as well as the evidence achieved when mTOR-related signalling components were tested as potential biomarkers of cognitive impairments in the clinical diagnosis of AD.
神经退行性变和神经原纤维变性是阿尔茨海默病（AD）认知障碍的两种主要病理机制。目前尚不清楚在疾病进展过程中哪些因素决定了神经元的命运。新出现的证据表明，mTOR依赖性信号传导参与了AD大脑中的这两种变性。本综述重点关注mTOR依赖性信号传导在AD发病机制中的作用。它总结了在理解其在神经退行性变和神经原纤维变性中的作用方面的最新进展，以及在AD临床诊断中将mTOR相关信号成分作为认知障碍潜在生物标志物进行检测时所取得的证据。
