Ebbens Fenna A, Georgalas Christos, Fokkens Wytske J
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.
Curr Allergy Asthma Rep. 2009 Mar;9(2):114-20. doi: 10.1007/s11882-009-0017-2.
The role of fungi in chronic rhinosinusitis (CRS) is not clear. Fungi can be detected in the nose and paranasal sinuses of virtually all CRS patients; however, they also appear to be present in healthy controls. Various theories attempt to explain the mechanisms by which fungi can exert an effect on sinus mucosa in susceptible individuals. Further studies are necessary to clarify the role of fungi in CRS, which fungal organisms (if any) are pathogenic, and what exactly characterizes the immunologic response to fungi that may result in the development of disease. However, in the absence of convincing immunologic data and evidence of clinical improvement of CRS after antifungal therapy, the case against the fungus remains unproven.
真菌在慢性鼻-鼻窦炎（CRS）中的作用尚不清楚。几乎所有CRS患者的鼻腔和鼻窦中都能检测到真菌；然而，健康对照者中似乎也存在真菌。各种理论试图解释真菌在易感个体中对鼻窦黏膜产生影响的机制。有必要进一步开展研究，以阐明真菌在CRS中的作用、哪些真菌（如果有的话）具有致病性，以及导致疾病发生的对真菌的免疫反应的确切特征。然而，在缺乏令人信服的免疫学数据以及抗真菌治疗后CRS临床改善证据的情况下，针对真菌的指控仍未得到证实。
