Sottilotta Gianluca, Mammì Corrado, Furlò Giuseppe, Oriana Vincenzo, Latella Caterina, Trapani Lombardo Vincenzo
Centro Emofilia, Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.
Clin Appl Thromb Hemost. 2009 May-Jun;15(3):356-9. doi: 10.1177/1076029607310218. Epub 2009 Feb 11.
Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism. In Europe, FVL is more prevalent in the north (7%) than in the south (3%), whereas FII G20210A is more common in the south (3% to 7%) than in the north (2% to 5%). In Italy, the prevalence is 2% to 3% for both. The aim of this study was to assess if these polymorphisms could be more frequent in the south than in the rest of Italy. In 105 blood donors in southern Italy, the prevalence of FVL and FIIG20210A was 9.5% and 5.7%, respectively. These prevalence data are higher when compared with published data. The results of this study are as high as those observed in Greece and the Middle East. The diffusion of FVL and FII G20210A in the Mediterranean, consequent to Phoenician and Greek colonization, could be a reason for the high prevalence observed.
凝血因子V莱顿突变（FVL）和凝血酶原G20210A突变（FII G20210A）是血栓栓塞的危险因素。在欧洲，FVL在北部的患病率（7%）高于南部（3%），而FII G20210A在南部（3%至7%）比在北部（2%至5%）更为常见。在意大利，两者的患病率均为2%至3%。本研究的目的是评估这些多态性在意大利南部是否比意大利其他地区更为常见。在意大利南部的105名献血者中，FVL和FII G20210A的患病率分别为9.5%和5.7%。与已发表的数据相比，这些患病率数据更高。本研究的结果与在希腊和中东观察到的结果一样高。由于腓尼基人和希腊人的殖民，FVL和FII G20210A在地中海地区的传播可能是观察到高患病率的一个原因。
