Krolczyk G, Gil K, Zurowski D, Jung A, Thor P J
Department of Pathophysiology, Medical College, Jagiellonian University, Cracow, Poland.
J Physiol Pharmacol. 2008 Dec;59(4):707-16.
A long term exposure of the gastric mucosa to inflammatory factors is suspected to alter the normal stomach motility. The consequence of it is an abnormal sensomotor response to food causing dyspeptic symptoms. Our study aimed to investigate the vagal afferents activity and the gastro-duodenal slow wave response to the mild gastric mucosa inflammation in rats. The gastric mucosal inflammation was induced by addition iodoacetamide to drinking water for 5 days. The gastro-duodenal slow wave, vagal nerve recordings and the gastric mucosa examination were performed on 6th day. The iodoacetamide irritated gastric mucosa presented the minimal inflammatory infiltration with mast cells. The vagal afferent activity was significantly increased after iodoacetamide treatment from 0.3 +/- 0.1 to 1.9 +/- 0.58 Hz, (p<0.05). The gastric slow wave accurate frequencies extracted from the fast Fourier transform spectra accelerated from 0.08 +/- 0.01 to 0.1 +/- 0.02 Hz (p<0.05). The duodenal frequencies remained unchanged (from 0.64 +/- 0.02 to 0.59 +/- 0.1 Hz). These results suggest that mild gastric mucosa irritation sensitizes vagal afferents and alters gastric but not duodenal pacemaker activity which may contribute to dyspeptic sensations.
长期暴露于炎症因子下的胃黏膜被怀疑会改变正常的胃动力。其结果是对食物产生异常的感觉运动反应，从而导致消化不良症状。我们的研究旨在调查大鼠迷走神经传入活动以及胃十二指肠慢波对轻度胃黏膜炎症的反应。通过在饮用水中添加碘乙酰胺5天来诱导胃黏膜炎症。在第6天进行胃十二指肠慢波、迷走神经记录以及胃黏膜检查。碘乙酰胺刺激的胃黏膜出现了伴有肥大细胞的最小程度的炎症浸润。碘乙酰胺处理后，迷走神经传入活动显著增加，从0.3±0.1赫兹增加到1.9±0.58赫兹，（p<0.05）。从快速傅里叶变换频谱中提取的胃慢波精确频率从0.08±0.01赫兹加速到0.1±0.02赫兹（p<0.05）。十二指肠频率保持不变（从0.64±0.02赫兹到0.59±0.1赫兹）。这些结果表明，轻度胃黏膜刺激会使迷走神经传入敏感化，并改变胃而非十二指肠的起搏器活动，这可能导致消化不良的感觉。
