A hematopoietic perspective on the promiscuity and specificity of Galpha16 signaling.

Galpha(16), a member of G(q) subfamily, is expressed exclusively in hematopoietic cells, and its expression is highly modulated during lineage differentiation. Although functional redundancy within G(q) subclass members has been observed in many established models, Galpha(16)possesses unique structural and biochemical properties not shared by other family members. Its broad receptor-coupling capacity and unique downstream binding partners and effectors allow the occurrence of both inositol lipid-dependent and -independent signals. Apart from its recognized biological functions in hematopoietic cell responses, the enlistment of complicated signaling pathways further signifies the importance of Galpha(16)in signal integration. This review aims to provide an updated appreciation and rational discussion of Galpha(16) signaling with regard to its promiscuity and specificity.