儿童室管膜瘤治疗中的新化疗策略和生物制剂
New chemotherapy strategies and biological agents in the treatment of childhood ependymoma.
作者信息
Wright Karen D, Gajjar Amar
机构信息
Division of Neuro Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Mailstop 260, Memphis, TN 38105, USA.
出版信息
Childs Nerv Syst. 2009 Oct;25(10):1275-82. doi: 10.1007/s00381-009-0809-7. Epub 2009 Feb 11.
Abstract
INTRODUCTION
With the limited role of current treatment regimens and potential associated side effects of radiation in young children with ependymoma, considerable effort is being focused on new chemotherapeutic strategies and biologic agents.
DISCUSSION AND CONCLUSION
Identification of those molecular changes underlying the development of ependymoma may, in time, lead to the development of not only novel therapeutic agents, but also specific patient-tailored therapies directed against known cell-signaling pathways.
摘要
引言
鉴于当前治疗方案在小儿室管膜瘤治疗中的作用有限，且放疗可能存在相关副作用，目前正致力于探索新的化疗策略和生物制剂。
讨论与结论
确定室管膜瘤发生发展的分子变化，或许最终不仅能催生新型治疗药物，还能开发出针对已知细胞信号通路的个体化精准疗法。
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