己酮可可碱对大鼠阿米卡星诱导的肾毒性的影响。
Effects of pentoxifylline on amikacin-induced nephrotoxicity in rats.
作者信息
Ozer Mehmet Kaya, Asci Halil, Oncu Meral, Yesilot Sukriye, Savran Mehtap, Bayram Dilek, Cicek Ekrem
机构信息
Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
出版信息
Ren Fail. 2009;31(2):134-9. doi: 10.1080/08860220802595492.
The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to determine renal malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine (Cr) levels. MDA production was found to be higher in AK group. PTX administration caused a significant decrease in MDA production. Morphological damage in rats given AK was severe in the kidney, whereas in rats given AK plus PTX, no histological changes occurred. It is concluded that PTX could be useful for reducing the nephrotoxic effects of AK.
在大鼠模型中，己酮可可碱（PTX）预防了阿米卡星（AK）的肾毒性。大鼠接受单次腹腔注射AK（1.2 g/kg），部分大鼠在注射前口服PTX（25 mg/kg）进行预处理。通过光学显微镜研究肾脏形态。还采集组织样本和躯干血液以测定肾脏丙二醛（MDA）、血尿素氮（BUN）和肌酐（Cr）水平。发现AK组的MDA生成较高。给予PTX导致MDA生成显著降低。给予AK的大鼠肾脏出现严重的形态学损伤，但给予AK加PTX的大鼠未发生组织学变化。得出的结论是，PTX可能有助于减轻AK的肾毒性作用。
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