儿童急性淋巴细胞白血病治疗期间骨密度的变化

Changes in bone mineral density during therapy in childhood acute lymphoblastic leukemia.

作者信息

Kaushik Ashlesha, Bansal Deepak, Khandelwal N, Trehan Amita, Marwaha R K

机构信息

Pediatric Hematology Oncology Unit, Advanced Pediatrics Center and Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Indian Pediatr. 2009 Mar;46(3):245-8. Epub 2009 Jan 21.

PMID:19213989

Abstract

Quantitative computed tomography was performed to determine bone mineral density (BMD) at initial presentation and following 6-months of therapy in children with acute lymphoblastic leukemia (ALL). Of 46 children enrolled, the complete set of observations was available in 32. The combined mean BMD of three lumbar vertebrae at diagnosis and during treatment were 167.1+/-27.4 and 148.8+/-31.4 mg/ cm3, respectively (P=0.001). Twenty six children (81.2%) had a decrease in BMD on treatment. The mean BMD for each of 3 vertebrae declined as well. The mean T-scores at diagnosis and during therapy were -0.15+/-0.9 and -0.86+/-1.0, respectively (P=0.001). Conventional radiographs revealed metaphyseal lucencies which were replaced with metaphyseal dense bands with therapy. To conclude, there was a significant reduction of BMD in children with ALL following 6- months of treatment.

摘要

对急性淋巴细胞白血病（ALL）患儿在初次就诊时及治疗6个月后进行定量计算机断层扫描以测定骨密度（BMD）。在纳入的46名儿童中，32名有完整的观察数据。诊断时和治疗期间三个腰椎的联合平均骨密度分别为167.1±27.4和148.8±31.4mg/cm³（P = 0.001）。26名儿童（81.2%）在治疗期间骨密度下降。三个椎体各自的平均骨密度也下降。诊断时和治疗期间的平均T值分别为-0.15±0.9和-0.86±1.0（P = 0.001）。传统X线片显示干骺端透亮区，治疗后被干骺端致密带取代。总之，ALL患儿在治疗6个月后骨密度显著降低。