Daniel Rodney S, Brown Alan N
Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, USA.
Am J Med Sci. 2009 Feb;337(2):153-4. doi: 10.1097/MAJ.0b013e31817f6df0.
Symmetric skin thickening of the limbs with deep fascial inflammation is the hallmark of eosinophilic fasciitis. We describe a woman who presented with unilateral progressive skin thickening. Examination of a full-thickness skin biopsy revealed an inflammatory process and fascial changes consistent with eosinophilic fasciitis. In contrast to other scleroderma mimics, eosinophilic fasciitis generally responds rapidly to glucocorticoid therapy. It is possible that unilateral eosinophilic fasciitis is under-recognized and can easily be misdiagnosed as another scleroderma variant if a full-thickness biopsy is not reviewed by a dermatopathologist. Recognition of this subtype of eosinophilic fasciitis is important given the profound differences in prognosis of eosinophilic fasciitis and other scleroderma variants.
四肢对称性皮肤增厚伴深部筋膜炎症是嗜酸性筋膜炎的特征。我们描述了一名出现单侧进行性皮肤增厚的女性。对全层皮肤活检的检查显示有与嗜酸性筋膜炎一致的炎症过程和筋膜改变。与其他硬皮病样疾病不同，嗜酸性筋膜炎通常对糖皮质激素治疗反应迅速。如果皮肤病理学家未对全层活检进行评估，单侧嗜酸性筋膜炎可能未得到充分认识，且容易被误诊为另一种硬皮病变体。鉴于嗜酸性筋膜炎与其他硬皮病变体在预后方面存在显著差异，认识这种嗜酸性筋膜炎亚型很重要。
